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KMID : 0604520130390030205
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Journal of the Society of Cosmetic Scientists of Korea
2013 Volume.39 No. 3 p.205 ~ p.213
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Enhancement of the Cosmeceutical Activity by Nano-encapsulation of Thiamine Di-lauryl Sulfate (TDS) with antimicrobial efficacy
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Seo Yong-Chang
No Ra-Hwan
Kwon Hee-Seok
Lee Hyeon-Yong
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Abstract
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This study was to improve cosmetical activity of thiamine di-lauryl sulfate (TDS) by encapsulation of nanoparticlewith lecithin. Results showed that most of the nanoparticles containing the TDS were well formed in roundshape with below 150 ∼ 200 nm diameter as well as they were fairly stable in various pH ranges by measuring zetapotentials. The nanoparticles of TDS resulted in 85% cell viability of human normal fibroblast cells (CCD-986sk) whenadded at the highest concentration (1.0 mg/mL). The nanoparticles of Acer mono sap showed highest free radical scavengeringeffect as 88.1% in adding sample (1.0 mg/mL), compared to TDS solution of non-encapsulation (81.6%). Thenanoparticles of TDS reduced the expression of MMP-1 on UV-irradiated CCD-986sk cells down to as 41.4%. The TDSsolution and nanoparticles showed significant anti-microbial activities agaionst the salmonella typhimurium and listeriamonocytogenes at 5 and 6 days as compared with control. Anti-microbial activities of TDS nanoparticles were similarto positive control. These results indicated that TDS nanoparticles may be a source for functional cosmetic agents capableof improving cosmetical activity such as antioxidant, whitening, and anti-wrinkling effects and can be further developedas natural preservative in cosmetics.
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KEYWORD
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Thiamine Di-lauryl Sulfate, cosmetical activity, Nano-encapsulation, anti-microbial activities
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